MK 791
《英文MSH詞典》MK 791
[入口詞] MK 791
[主題詞] Cilastatin
[藥動學] Protease Inhibitors
[英文釋義] A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic,IMIPENEM,is hydrolyzed by dehydropeptidase-I,which resides in the brush border of the renal tubule,cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukeotriene E4.